Minister Sisulu’s statement on South Africa’s vote on the situation of human rights in Myanmar

first_imgMinister Sisulu’s statement on South Africa’s vote on the situation of human rights in MyanmarAs part of the review of South Africa’s Foreign Policy, the Minister of International Relations and Cooperation, Ms Lindiwe Sisulu, is considering guidelines that will inform South Africa’s voting in various multilateral fora as South Africa’s prepares to assume its non-permanent seat in the United Nations Security Council (UNSC) for the period 2019-2020. These guidelines will also apply in other key political and technical agencies such as the Human Rights Council in Geneva and the Organization for the Prohibition of Chemical Weapons (OPCW) in The Hague.These guidelines were discussed extensively at the recently concluded Heads of Mission Conference and are underpinned by the values and principles of South Africa’s Constitution and its national interests. In this regard, the Minister will in due course give a voting directive to the South African delegation in New York pertaining to the situation of human rights in Myanmar, ahead of the upcoming Plenary of the United Nations General Assembly  (UNGA)  in December 2018.South Africa expresses its deep concern about the deteriorating human rights situation in Myanmar and calls for an end to the human suffering experienced by the Rohingya people. South Africa has consistently condemned human rights violations in Myanmar,  including at the recent Indian Ocean Rim Association (IORA) Council of Ministers meeting held in Durban.The Ministerial voting directive will supersede the South African vote that was cast on the situation of human rights in Myanmar at the 3rd Committee of the UNGA that took place on the 16th of November 2018.South Africa remains on guard at all times to ensure that votes on country-specific human rights resolutions are not used to engage in regime changes and destabilize countries.Enquiries: Ndivhuwo Mabaya, 083 645 7838, [email protected] BY THE DEPARTMENT OF INTERNATIONAL RELATIONS AND COOPERATIONlast_img read more

The Creative Motivation Behind Deep vs. Shallow Depth of Field

first_imgThis breakdown covers a range of creative motivations behind these two aperture settings, as well as the pros and cons of using each category.Determining the right aperture for a shot is just as important as choosing the right lens. Altering your aperture changes not only the depth of field (a.k.a. the blurry background), but it also controls the emotional tone of a shot. A higher F-stop is more fitting for wide vistas, while a lower one can create a feeling of isolation.In the following breakdown, I’ve narrowed the examples into two separate categories — shallow depth of field (F0.95 – F3.5) and deep depth of field (F4 – F16). Shallow Shots (F0.95 – F3.5)Let’s begin with a shallow depth of field (also known as a narrow depth of field). This low aperture control creates the feeling of isolation between the subject you’re capturing and the world around them because the background is blurrier. The lower the number, the more your primary subject stands out from their surroundings. Using a shallow depth of field enhances the visual style, and it creates a beautiful backdrop.Cons?Despite its dreamy quality, dialing your aperture any higher than an F2.8 creates the ongoing problem of keeping things in focus. Nailing that crisp shot can become tricky since the range of attention is so narrow.Getting Dynamic with Deep Shots (F4 – F16)I’ll openly admit that I’m a sucker for shallow depth of field shots. They’re creamy, dreamy, and, well . . . just super cinematic. That being said, there are some significant perks to filming with a higher aperture setting. First off, everything is in focus. You won’t struggle to get that razor-sharp image at an F16, because there’s no depth. This is helpful if you’re using manual focus, or shooting in nature and trying to capture a massive landscape with all its beautiful details.Cons?The most obvious con for deep depth is that there’s no depth. There’s nothing to separate your subject from the background. This can make character-driven shots look ugly, due to the distraction of the background. Another pitfall comes from your dirty sensor. That’s right! Capturing anything with an F-stop higher than an F4 brings out all the nasty specs on your sensor. Since there’s no depth of field, any piece of dust resting on your sensor or lens becomes much more present in the final frame.Interested in the tracks we used to create this video?“Blue Blood” by Aulx Studio“Success Story” by Vincent ToneLooking for more on cinematography? Check these out.Choosing Aspect Ratio: A Guide to Everything You Need to KnowWhy Filmmakers and Photographers Prefer to Use Soft LightCapturing the Cinematic Moment: Creative Uses for a Color MeterWhere to Find Vintage Lenses (and Tips on How to Use Them)4 Older Cinema Cameras That Hold Up to Today’s Standardslast_img read more

You Have Work To Do

first_imgYou have work to do.Why are you reliving the mistakes you made yesterday right now? Why are you still talking about the deal you lost a month ago? Living in the past keeps you from moving into the future.Why are you dwelling on what other people think of you? Why are you worried about someone else’s approval. Why are you waiting for permission that isn’t coming? You alone are responsible for your life, and this means that you have to trust yourself.Your manager, your CEO, your competitors, your government, and your parents are not capable of preventing you from doing the meaningful work you should be doing right now. In fact, no one is thinking about how to stop you. The only obstacle between you and the meaningful work you should be doing is staring back at you in the mirror each morning.There are thousands of distractions that continually and unceasingly compete for your attention. They are legion. Some of these distractions may be worth your time and attention. But no distraction is worthy of the time and energy you need to do your real work. Only you can put first things first.The small fires that fill up your inbox will burn up all of your psychic bandwidth and all of your emotional energy if you let them. If you are vigilantly keeping guard in hopes of stomping out every small flame, you will burn yourself. The fire that should be your priority every day is the one that is burning inside you. Your job is to feed it, not allow it to be extinguished.You have work to do. You should be doing this work now. You should be prioritizing this work and putting it above everything else.last_img read more

Rice biophysicists model genome mechanics

first_img Minimal Chromosome Model (MiChroM) developed at Rice University predicts chromosome conformations by using the idea that chromatin — which consists of DNA and hundreds of proteins that interact with the genetic material — can be subdivided into types based on their biochemical interactions. Chromatin types, which are distinct from DNA sequence, are partially epigenetically controlled and change during cell differentiation, thus constituting a link among epigenetics, chromosomal organization and cell development. A) The matching conformation of a human chromosome as it appears from Hi-C experiments (lower triangular part of image) and from MiChroM simulations (upper diagonal part). B) A pictorial representation of MiChroM, in which different colors indicate different chromatin types. C) MiChroM output of the 3-D conformation of a human chromosome. (Credit: Illustration by Michele Di Pierro/Rice University) AddThis at Rice University have developed their theoretical Minimum Chromatin Model to help explain how the human genome folds. Clockwise from top left: Erez Lieberman Aidan, Michele Di Pierro, Peter Wolynes and José Onuchic. (Credit: Jeff Fitlow/Rice University)Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,910 undergraduates and 2,809 graduate students, Rice’s undergraduate student-to-faculty ratio is 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice is ranked No. 1 for happiest students and for lots of race/class interaction by the Princeton Review. Rice is also rated as a best value among private universities by Kiplinger’s Personal Finance. To read “What they’re saying about Rice,” go to Share2Editor’s note: Links to high-resolution images for download appear at the end of this release. David [email protected] [email protected] biophysicists model genome mechanics  Rice University simulations help explain how genomes take form of 3-D chromosomes HOUSTON – (Sept. 26, 2016) – Rice University scientists trying to solve the ultimate puzzle — the architecture of the human genome — have snapped another piece into place.Researchers at Rice’s Center for Theoretical Biological Physics have developed a model to explain one part of the mechanism, the folding of chromosomes during a cell’s interphase. Their work offers the possibility of predicting the three-dimensional organization of entire genomes from limited one-dimensional data.The researchers have used experimental information about one human chromosome to create their Minimal Chromatin Model (MiChroM) and have shown that their model generates accurate 3-D structures for all other chromosomes in the cell.The new computational tool will help researchers understand how genome architecture contributes to cell development and differentiation.The paper in the Proceedings of the National Academy of Sciences this week suggests that a true model of chromosome architecture should include not only the code embedded in one’s DNA but also the entire complex of molecules in the cell nucleus, collectively known as chromatin, as they all influence the 3-D arrangement of the genome.According to the Rice researchers, all of these factors can be recapitulated by subdividing chromatin into just a few types based on their biochemical interactions. They say this simplifies the model and suggests the existence of a hidden code in the genome.“Chromosomes are very long polymers,” said Rice postdoctoral researcher Michele Di Pierro, co-lead author with former postdoctoral researcher Bin Zhang, now an assistant professor at the Massachusetts Institute of Technology. “The way they’re compressed in a very small space is cell-specific: A lung cell will be different from a brain cell or a liver cell. Part of the difference between these cells is stored in the way the chromosome is folded inside the nucleus.“So even though we have the same DNA in every cell, the information about different folds in different cells, which is important to cell development and differentiation, is somewhere else. It’s known that this information is partially contained in epigenetics and not in DNA,” Di Pierro said.“Chromatin types are not simply DNA sequences,” said biophysicist and co-author José Onuchic. “Types are determined by the DNA, the histones and their biochemical modifications, and all the proteins in the cell nucleus. All these factors are part of what we mean by epigenetics and all have an impact on chromosome organization and cell development.”The Rice team used data drawn from Hi-C experiments, which identify contacts formed between faraway parts of chromosomes as they fold and loop inside the cell nucleus. Erez Lieberman Aiden, a researcher at Rice and at Baylor College of Medicine and a co-author on the new study, led the team that originally created Hi-C.More recently, scientists in his laboratory reported the highest-resolution Hi-C map ever generated, a dataset 1,000 times the size of the human genome. The Rice researchers, led by Onuchic and biophysicist Peter Wolynes, used this immense dataset to see if chromosomes simulated with MiChroM matched the real ones. They did.MiChroM “explains the physics of the system,” Di Pierro said. “It’s remarkably efficient at predicting a lot of the known behaviors and effects, well beyond what’s built into the model. This is a good indication that the physics is right.“It’s still not clear how epigenetics leads to different folds in different cells,” he said. “But here we’re beginning to establish a link between the biochemical modifications through epigenetics and the structure.”The researchers applied principles similar to those they used to pioneer protein folding, in which the sequence of amino acids in a protein defines its energy landscape; this in turn prescribes how it will fold. In the current research, they show the sequence of chromatin types determines genome folding.“We’re making a tool that allows us to predict chromosome conformation from a limited set of information,” Di Pierro said. “This is part of a process in which we’re investing a lot of effort.”The Rice team’s goal is to simulate the mechanisms of the human genome through all of its phases. Previous papers have studied mechanistic details of the process that takes place as a cell moves from interphase, in which it spends most of its time, to the dramatic event of mitosis.“The new paper is a step into the normal life of a cell and allows us to study how its 3-D organization affects its function,” Wolynes said. “The breakthrough that’s been achieved in this paper will soon give us the mathematical tools to study chromosomes without needing any structural experimental data.”The National Science Foundation, the Cancer Prevention and Research Institute of Texas and the Welch Foundation supported the research.-30-Read the abstract at Rice News and Media Relations via Twitter @RiceUNewsRelated materials:Center for Theoretical Biological Physics: https://ctbp.rice.eduThe Center for Genome Architecture (Aiden Lab): http://www.aidenlab.orgWiess School of Natural Sciences: http://natsci.rice.eduImages for download:last_img read more