CALGARY – The Yes side of the Calgary 2026 bid is getting a boost from a huge ’88 legacy.Michael “Eddie” Edwards, better known as Eddie the Eagle, landed at the Calgary International Airport Sunday, telling Calgarians to “check the little box that says ‘yes’” on Nov. 13. “Vote for another Olympics!” he smiled, adding the Winter Games are a very special event.The Brit who owned hearts of Calgarians and Canadians alike in 1988 told a group of admirers and reporters waiting at YYC it’s great to be back in Calgary.“I was in Calgary for the Stampede in July so it’s always nice to come back to Calgary… I feel like this is my home–it’s where Eddie the Eagle was born shall I say.”The Eagle has landed at @FlyYYC! Eddie the Eagle is in Calgary to share his support for a Calgary 2026 Olympic Bid @660NEWS. @BTCityNewsCGY pic.twitter.com/lxxMzUVtqR— Kass Patterson (@kassonair) November 4, 2018He is not the first athlete to support the yes side of the debate; Jarome Iginla, Haley Wickenheiser, Jesse Lumsden, and Kaillie Humphries are a just a handful of the hometown heroes pushing for a yes vote.Eddie says an Olympic games can bring a lot to a city, like enthusiasm, excitement, love of sports, and camaraderie, pointing to the ’88 games. “I think back…Calgarians were so proud to host the Olympic Games. It was such a special Olympics. I’m really biased,” he said, adding it was his dream to compete in a games.“It was a fantastic Olympics.” As far as the magic of a games goes, Eddie told CityNews the Olympics are not made special by the “characters” that come out of it.READ MORE: Calgary Olympic debate shifting towards plebiscite arguments“I’m not sure if there will be other characters like myself anymore at the Olympics, but that doesn’t make the Olympics any less special. I think all the athletes that go there it’s their dream to be there and they want to do well and it’s always a very special event, and I’m hoping that will remain so despite other difficulties.”He says hopefully a 2026 Olympics will be bigger and than the games that put him on the map and says it’s time to put Calgary back in the spotlight. He added the 2026 games don’t necessarily mean Calgary needs to build new facilities. “Why build new ski jumps if you’ve already got them? Use what you’ve got.”READ MORE: The debate over Olympic infrastructure for a Calgary 2026 bidIf Calgary does vote yes and moves forward with a bid, Eddie says he will absolutely be there for it eight years from now.“Of course–if I’m still alive!” he joked.Calgarians vote in a non-binding plebiscite Nov. 13.-with files from Kass Patterson, 660 NEWS and Derek Brade, CityNews
President Bill Clinton has announced a roster of international leaders from the private and public sectors across Latin America, the Caribbean, Canada, and the United States who will participate in a one-time Future of the Americas convening on December 11 at the University of Miami in Miami, Florida.This convening is part of President Clinton’s long-standing commitment to economic prosperity, investment, and innovation across the western hemisphere, through his work in office and post-presidency through the Clinton Foundation.Twenty years after President Clinton convened the first Summit of the Americas, this convening will bring leaders together from across the hemisphere to create space for them to have a conversation about the next twenty years, with a focus on how to strengthen investment, jobs, health, and education. The Future of the Americas will complement the official Summit of the Americas in April 2015.The agenda of President Clinton’s Future of the Americas convening will encourage cross-sector collaboration across Latin America, the Caribbean, Canada, and the United States. Discussion topics will include energy, infrastructure, the environment, agriculture, small and medium-sized enterprises, women and girls, technology, chronic diseases, nutrition, primary education, and vocational training. This convening is a working meeting, with an emphasis on interactive, roundtable discussions.“I’m looking forward to our Future of the Americas discussions in Miami. There’s been tremendous progress across our hemisphere since we first came together twenty years ago, and now more than ever, it’s clear the next twenty years in our hemisphere will depend largely on the actions that leaders from all sectors and countries take today,” said President Clinton. “This meeting will give people an opportunity to focus on key challenges and opportunities – around jobs, education, health and the need for inclusive political, economic, and social policies. I’m thankful for the leadership of the people who are participating, and hopeful that our discussions will re-energize their efforts to shape our shared future in ever more positive ways.”Participants in the Future of the Americas discussions include Dr. Valentin Abe, Founder, Caribbean Harvest; Gastón Acurio, Chef, La Mar by Gastón Acurio; Fidel Andueza, Head of the Americas, Libra Group; Carlos Julio Ardila, Vice President of the Board, Organización Ardila Lülle; Steffano Bertozzi, Dean, School of Public Health, University of California at Berkeley; Carlos Bulgheroni, CEO, Bridas Energy; Luis Carlos Sarmiento Angulo, President, Grupo Aval; Adriana Cisneros, CEO and Vice Chairman, The Cisneros Group of Companies; Gustavo Cisneros, Chairman, The Cisneros Group of Companies; Henry G. Cisneros, Executive Chairman, CityView Companies; Vicky Colbert, Executive Director, Fundación Escuela Nueva; David Crane, President and CEO, NRG Energy; Hernando de Soto, President, Institute for Liberty and Democracy; Jorge Errázuriz, Partner, BTG Pactual; Emilio and Gloria Estefan, Estefan Enterprises; Alfonso Fanjul, CEO, Fanjul Corp; Angélica Fuentes, CEO, Grupo Omnilife; Alejandro García Padilla, Governor, Commonwealth of Puerto Rico; Frank Giustra, President and CEO, Fiore Financial Corporation; Rolando González-Bunster, Chairman and CEO, InterEnergy Holdings Ltd.; Nizan Guanaes, Chairman and Founder, Grupo ABC; Gabriela León, CEO, GRESMEX SA de CV; Phillip Levine, Mayor, Miami Beach; Alfredo Mesa, Executive Director, Marlins Foundation; Thomas F. McLarty, Chairman, McLarty Associates; Luis Alberto Moreno, President, Inter-American Development Bank; Stanley Motta, President, Motta Internacional, S.A.; Dyer Narinesingh, President, University of Trinidad and Tobago; Eduardo Padrón, President, Miami Dade College; Nicholas Prouty, President, Putnam Bridge Funding Jennifer Pryce, Founder and CEO, Calvert Foundation; Frank Rainieri, President and CEO, Grupo Puntacana; Julissa Reynoso, U.S. Ambassador to Uruguay; Carlos Rodríguez-Pastor, Chairman and CEO, Intercorp; David Rothkopf, President and CEO, Garten Rothkopf, Israel Ruiz, Executive Vice President and Treasurer, Massachusetts Institute of Technology; Alejandro Santo Domingo, Managing Director, Quadrant Capital Advisors, Inc.; Juan Manuel Santos, President of the Republic of Colombia; Donna Shalala, President, University of Miami; Carlos Slim, Chairman, Grup Carso; Javier Soto, President and CEO, The Miami Foundation and Gerardo Werthein, Chairman, Caja de Seguros S.A., and many others.For more information, a complete list of featured participants, and the most up-to-date schedule visit www.clintonfoundation.org/futureoftheamericas.
Rabat – French Former president, Nicolas Sarkozy, praised Morocco’s stability on Saturday under the leadership of King Mohammed VI.Speaking at the headquarters of his party before several hundred new members of his party about the future of the southern Mediterranean region, Sarkozy cited the stability of Morocco as an example of progress in the world.The former French president said that Morocco is a country where development is positive, representing a unique model apart from the landscape in the rest of the southern Mediterranean. “In Morocco, fortunately we have a great King, who named an Islamic Prime Minister, but who rules Morocco.”The former French president warned that the entire Middle East is collapsing, “We must push for the emergence of moderate regimes,” He said.For example, “The international coalition has not even been able to prevent Daesh from setting foot in Palmyra, the cradle of culture and humanity,” said Sarkozy.According to Sarkozy, ”the vast majority in the Middle East who want peace, say the international community is not determined to defend it.”Following the deadly civil clashes in Syria and Iraq, he predicted that four or five countries will emerge out of Iraq and Syria.
The stay order was issued to the Financial Crimes Investigation Department (FCID) against arresting Rajapaksa over the alleged misappropriation of public funds.The FCID was looking to arrest Gotabaya Rajapaksa over the use of public funds for the construction of the D.A.Rajapaksa museum when he was the Secretary of Defence. A stay order issued by the Court of Appeal preventing the arrest of former Secretary of Defence Gotabaya Rajapaksa, has been further extended February 15.The stay order had earlier been extended from December 15 till today. Gotabaya Rajapaksa had filed a petition in court against the move to arrest him. (Colombo Gazette)
The agreement provides for multilateral accords deals the joint UN Programme on HIV/AIDS (UNAIDS), the Brazilian Government and other developing countries and includes setting up an International Centre for Technical Cooperation on AIDS based in Brazil. “The new initiative will give other countries the necessary tools to effectively fight AIDS, now that financing is greatly increasing,” UNAIDS Executive Director Peter Piot said in the Brazilian capital Brasilia yesterday. “Making this money work is now a priority. We urgently need to identify new ways for countries to build technical capacity to tackle the epidemic, the largest human development crisis in history.” Dr. Piot, who met with Brazilian President Luiz Inacio Lula da Silva, paid tribute to the country’s “unrivalled leadership and creativity” as “a model in tackling both HIV prevention and treatment head-on.” He noted that 20 years into the pandemic “the linkages between poverty, hunger and AIDS are now more evident than ever.”The new centre will initially be funded by UNAIDS and the Brazilian Government. Additional resources will be raised through the private sector and international foundations.In a related development, the Global Fund to Fight AIDS, Tuberculosis and Malaria, an initiative of Secretary-General Kofi Annan, unveiled its first communications campaign today in Paris, aimed at raising France’s public awareness of the Fund as a global financing mechanism and winning the commitment of donors.Over 40 magazines and newspapers have so far agreed to support the campaign, including daily newspapers, news magazines, women’s publications, television magazines and leisure publications. Television will show 30-second spots and the cinemas a 50-second version.
A 19-year-old, East Bank Demerara (EBD) teen was on Tuesday morning arraigned for the indictable offence of attempted murder at the Georgetown Magistrates’ Courts.Moris Khan of Old Road Craig, EBD was not allowed to plead to the indictable charge read to him by the Chief Magistrate, Ann McLennan.The charge against him alleged that on February 15, 2018 at Old Road Craig, he unlawfully and maliciously wounded Oswald Obrien with intent to murder.According to Police Prosecutor, Bharat Mangru the Virtual Complainant (VC) is currently hospitalised at the Georgetown Public Hospital Corporation (GPHC).He revealed that on the day of the incident, the defendant allegedly took up a bicycle bar and dealt Obrien several lashes about his body.The man fell to the ground unconscious and was picked up and rushed to the hospital where he remains in a serious condition.Bail was refused and Khan was remanded to prison to return on March 16, 2018. Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)Related17-year-old charged with attempted murder of 15-year-old schoolmateJanuary 26, 2018In “Court”Vendor arraigned for murder of Timehri teenApril 26, 2019In “Court”Teen in cellphone row charged with attempted murder of colleagueJune 13, 2018In “Court”
Image: Wanderley Massafelli 23 Comments Jun 22nd 2017, 3:27 PM He was shot twice, an unarmed man on his way back to an hotel… There’s no doubt he was at the edge of his life on that occasion.Dr O’Keeffe said Mr Hanrahan had been left with a sense of “heightened tension” and this was probably what led to what occurred on the night of the offences.The defendant was left in a “precarious situation” by this court case and it would have ramifications beyond the walls of the courtroom, Mr O’Gorman said.He had admitted that he “shouldn’t have hit the lady” when speaking to Dr O’Keeffe. The solicitor asked for “leniency” and to give Mr Hanrahan time to pay compensation to the victims.Psychological reportThe court heard there were witness expenses totalling €1,206.10, including €510 for dental treatment needed by Emer Kelly as a result of being punched in the face.Judge MacGrath said she had ordered a psychological report because of the serious incident suffered by Brian Hanrahan in New Orleans and it came to her mind that he might have been suffering from post-traumatic stress disorder (PTSD).However, Dr O’Keeffe’s report noted that the defendant wasn’t suffering from PTSD, before the assaults in Nenagh.“The assault, in particular on Ms Kelly, was a serious assault on the night in question,” the Judge said.“Mr Hanrahan, with his background, ought to have been able to deal with that matter,” she said.These matters are deserving of a custodial sentence.She decided that in view of the matters outlined by Mr O’Gorman, and the fact Brian Hanrahan had no previous convictions, she would suspend the prison sentences.She imposed a six-month sentence, suspended for two years, for the assault on Emer Kelly and a concurrent three-month sentence, suspended for a year, for the assault on Aisling King.Recognisances in the event of an appeal were fixed at the defendant’s own bond of €1,000 in each case. There was no comment afterwards from his solicitor on whether or not there will be an appeal.Read: Water supplies running low in many areas due to dry weather >Read: Grenfell Tower: Three samples of cladding on UK high rises found to be combustible > Image: Wanderley Massafelli Garda (33) convicted of assaulting two women will not face jail Brian Hanrahan (33) of Ballintotty, Nenagh was convicted earlier this year. My client was a victim of an horrific, unprovoked attack where he was mugged while making his way back to a hotel, as could happen to anybody in any place in the world these days. Share205 Tweet Email Tweet thisShare on FacebookEmail this article 21,405 Views A GARDA WITH a “string of commendations” convicted of assaulting two women in a row over a lift in a car has been given a six-month suspended sentence.Father-of-two Brian Hanrahan (33) of Ballintotty, Nenagh, Co Tipperary, was convicted earlier this year of two offences of assault causing harm.He had denied the charges which involved punching and kicking one woman and hitting the other victim.The assaults occurred when a row broke out over payment for a lift home after a night out in Nenagh in March 2016.At a sentencing hearing, Judge Elizabeth MacGrath described the assault on one of the victims, Emer Kelly, who was punched in the jaw and kicked, as “a serious assault” and said that the other victim, Aisling King, had been acting as a “good Samaritan” by coming to her friend’s aid when she was slapped on the face.Sentencing had been adjourned in February to allow for the preparation of probation and psychological reports relating to Hanrahan. He had no previous convictions.Mr Hanrahan was in the news in 2015 when he was shot in the back and leg during a botched robbery at an ATM machine during a holiday in New Orleans. He was hospitalised in the United States and underwent emergency surgery before being allowed to return home and eventually back to garda duty.His solicitor Daniel O’Gorman said Brian Hanrahan was a garda with “a string of commendations,” and an excellent work record and was a “great colleague” and very popular.He lives in a small community and does charity work, voluntary work and community work, the solicitor said, and had a “previously unblemished” record. He is married with two children, aged 10 months and three years, and has a mortgage.Alcohol was “certainly a factor” in the events on the night of the offences, Mr O’Gorman said, but a Dr O’Keeffe, who carried out a psychological report, “signposts” the incident in early 2015 in New Orleans. Thursday 22 Jun 2017, 3:27 PM Short URL https://jrnl.ie/3458224 By Conor Kane
According to reports in England, Toby Alderweireld is set to be targeted by Paris Saint-Germain with the club willing to pay for his £10m a year demandsThe defender looks increasingly likely to leave Tottenham in the summer after failing to agree on new terms for a new deal. Alderweireld has been demanding a new five year deal with a wage of around £200,000 per week, which is something that club chairman Daniel Levy is unwilling to match due to the Belgium international now being 29 years old.Now the Daily Mail has reported that PSG, among with Manchester United, are interested in securing Alderweireld’s services for the start of next season with the Ligue 1 leaders prepared to meet his demands in a bid to convince him to come to the Parc Des Princes.Spurs manager Mauricio Pochettino has told Alderweireld that he is free to leave the club at the end of the season with Levy now in charge of the matter.Neymar can win the Ballon d’Or, says Ander Herrera Andrew Smyth – September 13, 2019 An “excited” Ander Herrera believes new Paris Saint-Germain team-mate Neymar is a contender for the Ballon d’Or alongside Kylian Mbappe.After suffering a hamstring injury against Real Madrid in the Champions League group stages, back in November, Alderweireld has struggled to regain his place in the starting 11 with an ongoing set of fitness and injury issues having hampered his progress.Belgium coach Roberto Martinez warned Alderweireld, last week, that he must start getting regular game time at Spurs again, if he is to make the final squad for the World Cup.
The Marlins will erect a statue of Jose Fernandez outside Marlins Park, according to the team’s owner, Jeffrey Loria.Fernandez and two other men died last September when, in the middle of the night, his boat slammed into a jetty that extends off the southern tip of Miami Beach.Loria told ESPN about the team’s plans to create a statue towering “9 or 10 feet tall” because the pitcher was “larger than life.” The Marlins had already announced that no player will ever wear Fernandez’s number 16 again.Fernandez defected from Cuba at age 15, won the NL Rookie of the Year award and became a two-time All-Star. His enormous popularity in South Florida bridged the divide between the franchise and fans antagonized by too much losing and too many payroll purges.Fernandez left behind a girlfriend who is expecting their first child, the mother who came with him to the United States and the grandmother who helped raise him.A toxicology report found that the star pitcher had cocaine and alcohol in his system at the time of the crash, and investigators later determined that he was driving the boat.Loria, who buys and sells art, said he is attending to the sculpture personally. “I went through hundreds and hundreds of photographs with the sculptor and gestures of Jose’s face to try and make it perfect,” he told ESPN’s Jerry Crasnick. “No one else is going to get involved in a piece of sculpture other than me, right? I’ve spent 50 years in that world.”The owner, who is considering selling the team, hopes the statue will be finished before the year ends.“We’re going to cast it in bronze and paint the glove the red-orange that Jose would like, and that will be the only color on it. I don’t want to make it kitschy, but that was his favorite thing. Hopefully we’ll see it in six months or so. It’s a very long process to cast a sculpture that’s 9 or 10 feet high, as opposed to 6 feet,” he told ESPN.Copyright 2019 Sunbeam Television Corp. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Although absentee and questioned ballots yet to be counted could change the outcome, it is likely that Proposition 2, which legalizes recreational marijuana use in Alaska, has gained voter approval. Proposition Two supporters took more than 52 percent of the vote Tuesday night. Yes on 2 organizer Taylor Bickford says the returns show that voters want a change.“There’s still a lot of votes to be counted. We’re cautiously optimistic about the result. But what is absolutely clear, is that a majority of Alaskans want to see marijuana prohibition end, they recognize that it has failed and it’s time for a new approach. So, regardless of how the results carry out tonight, there’s no question that Alaskans want to see marijuana prohibition end in this state.” With all the precints counted it appears that the NO on 2 vote is just under 48 percent of the ballot. Hilary Walker is with the NO on 2 campaign “We’re still waiting for all the votes to come in. We’re hopeful, so, we’re hopeful, a lot of voices still need to be heard.”At least 22 thousand absentee and questioned ballots still need to be counted. State election results are unofficial until certified.
Hyderabad: Amid birthday wishes, Tollywood’s most loved Upasana Kamineni Konidela has released an informative music video about the on going water crisis in India. The music video features Telugu rapper Roll Rida who is known to be vocal about social issues in his music. The video touches upon important issues concerning the depleting water reserves and what we can do to reverse the damage.
Bob Marley and weed have virtually been synonymous for ages now. To cement this link, Privateer Holdings – a private equity firm – and the estate of the legendary reggae musician are launching a global marijuana brand “Marley Natural”, which is going to be the first-ever legal cannabis company.Marley Natural is a cannabis brand dedicated to Bob Marley’s beliefs of social justice, love and respect and his faith in the healing powers of “the herb”.”Marley Natural is the world’s first global cannabis brand. Our mission is to champion Bob’s voice and his insight to help people realise the positive potential of cannabis for the mind, body, and spirit. Along the way, we want to help undo the suffering and injustice of cannabis prohibition around the world,” the brand’s official website states.The Products”Herb is the healing of a nation, alcohol is the destruction.”- Bob MarleyMarley Natural will be offering heirloom cannabis strains, including some of Bob Marley’s Jamaican favourites. But that’s not all. Balms and lotions infused with “the herb” will also be marketed. Limited edition accessories and handcrafted products mainly used to consume and store weed will be offered.”Marley Natural is committed to cultivating and crafting every product we will offer* with respect for nature, responsibility, and compassion,” the website states.The products will start shipping from 2015 onwards and will be available only in regions where cannabis is permitted by jurisdictions. For now, Marley Naturals products are intended to be distributed across the US, but would start shipping worldwide later.The PartnershipBob Marley’s family said they were collaborating with Privateer Holdings in this venture because the company understood and respected Marley’s legacy. The “Could You Be Loved” hitmaker was an ardent supporter of cannabis usage and has promoted its legalisation.Privateer Holdings and Bob Markey’s estate have signed a 30-year licensing deal. A range of headphones and audio devices as well as coffee products are on the anvil too.”Marley Natural is a partnership between two cannabis pioneers,” Brendan Kennedy, CEO of Privateer Holdings said in a statement.”The Marley family has been an admired voice in the cannabis movement for over 50 years and Privateer Holdings is the leader in building professional, mainstream cannabis brands. We’ve learned a lot over the past year about Bob’s views towards cannabis and how he viewed the herb differently. We are honoured to work with the Marley family to bring his voice to a professional, authentic and modern brand that will be a defining first in the cannabis industry,” Kennedy added.Market ReachCurrently, weed has been legalised in the US states of Colorado and Washington for recreational purposes. Some others have permitted prescribed medical usage of the herb. But the global market is still tight on regulations regarding cannabis. Won’t this hamper growth of the company?Zach Hutson, a company spokesperson told The World Today that the market for Cannabis is huge.”The UN estimates the global cannabis market, both illicit and the legal market, at about $150 billion. We think it could be a little bit higher than that. In the US, we see it as a $40 to $50 billion total opportunity.”
On Sunday June 21 Baltimore will host its own Climb Out of the Darkness as part of the world’s largest event raising awareness for maternal mental illnesses such as postpartum depression (PPD), anxiety, OCD and psychosis. As part of the Climb, survivors all over the world – dubbed Warrior Moms – are organizing to climb, hike or walk at a local mountain or park to symbolize their collective rise out of the darkness and stigma of maternal mental illnesses, as well as to raise funds for Postpartum Progress, a non-profit organization and online community of support resources for women around the world.The Baltimore Climb will be held at Druid Hill Park on June 21 at 10 am. All participants must register beforehand at https://www.crowdrise.com/carrieflora-COTD2015/ (Registration is FREE). Contact Carrie Flora at 410.274.1117 for more information.
Food peptides activate bitter taste receptors (PhysOrg.com) — Though not very well known in the United States, at least until the past few years, the miracle fruit is a cranberry like fruit that has the unique property of being able to make acidic or bitter foods taste sweet. And while the protein that makes this possible has been known for quite a while, just how exactly it did its trick has been a mystery; until now. A team of Japanese and French researchers working together have solved the puzzle and have published the results of their efforts in the Proceedings of the National Academy of Sciences. Miracle fruit, the berry of the Synsepalum dulcificum plant, grows naturally in West Africa and the locals there have long known of its sweetening properties. Pop one of the little berries in the mouth and for an hour, foods like pickles, beer, grapefruit or lime, taste like sweet versions of their former selves. More recently, the effects of the miracle fruit have been popularized by flavor-tripping parties, so named because of the odd sensational resemblance to the effects of hallucinogens. Or as Keiko Abe, one of the team leads, reports, the effect is rather magical.To get to the bottom of how the miracle fruit performs its magic, the team grew human kidney cells in a dish that were engineered to produce sweet receptor proteins. They then applied a chemical that caused the receptor cells to light up when activated. Next, they applied miraculin, the protein in miracle fruit that is responsible for the sweetening effects. After that they added different substances with different pH levels and found that the miraculin had three distinct impacts on the receptors. At low levels there is little effect, at medium levels the miraculin boosted response and at high levels the receptors were activated on their own.This all happens, the researchers say, because the miraculin protein changes shape when exposed to acids. The higher the level, the more it changes shape. And because the protein binds very strongly to the receptors in the human tongue, those changes in shape change the way the receptors react when acids are introduced into the mouth. The bottom line is, the higher the pH level in a substance, the sweeter it tastes to the person doing the tasting.The end result of this research might be the introduction of a whole new kind of artificial sweetener, either as an ingredient, or as an additive by users wishing only to sweeten ordinary foods. And now that the effects of miraculin are better understood, researchers will next try to see if they can create it from scratch rather than having to rely on Mother Nature to grow it for them. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Photo of Miracle berry (Hamale Lyman/Wikipedia) Citation: Researchers uncover secrets of ‘miracle fruit’ (2011, September 27) retrieved 18 August 2019 from https://phys.org/news/2011-09-uncover-secrets-miracle-fruit.html Explore further More information: Human sweet taste receptor mediates acid-induced sweetness of miraculin, PNAS, Published online before print September 26, 2011, doi: 10.1073/pnas.1016644108AbstractMiraculin (MCL) is a homodimeric protein isolated from the red berries of Richadella dulcifica. MCL, although flat in taste at neutral pH, has taste-modifying activity to convert sour stimuli to sweetness. Once MCL is held on the tongue, strong sweetness is sensed over 1 h each time we taste a sour solution. Nevertheless, no molecular mechanism underlying the taste-modifying activity has been clarified. In this study, we succeeded in quantitatively evaluating the acid-induced sweetness of MCL using a cell-based assay system and found that MCL activated hT1R2-hT1R3 pH-dependently as the pH decreased from 6.5 to 4.8, and that the receptor activation occurred every time an acid solution was applied. Although MCL per se is sensory-inactive at pH 6.7 or higher, it suppressed the response of hT1R2-hT1R3 to other sweeteners at neutral pH and enhanced the response at weakly acidic pH. Using human/mouse chimeric receptors and molecular modeling, we revealed that the amino-terminal domain of hT1R2 is required for the response to MCL. Our data suggest that MCL binds hT1R2-hT1R3 as an antagonist at neutral pH and functionally changes into an agonist at acidic pH, and we conclude this may cause its taste-modifying activity. © 2011 PhysOrg.com
Celebrate the re opening of BoracayCelebrate the re opening of Boracay with Cebu Pacific’s Seat SaleBe the first to experience the newly reopened Boracay with the Philippines’ leading airline, Cebu Pacific (PSE: CEB), with an all-in seat sale to the island, via Manila.Cebu Pacific will resume flights to and from Caticlan—the main gateway to Boracay, from October 26, 2018 onwards. CEB will be the first airline to land in Caticlan, allowing passengers to be amongst the limited few to set foot on the rejuvenated island and its famed beaches, following a six-month closure for its rehabilitation, restoration and recovery.To celebrate the island’s reopening, Cebu Pacific is holding a seat sale from today until 26 October. Travellers from Singapore can fly to Boracay via Manila for as low as SGD142 from 1 January to 31 March 2019.Boracay was ranked as the second island in the world by readers of the esteemed Conde Nast Traveller in 2018 for its breath-taking sunsets, pristine white beaches and vibrant nightlife.And with low fares that can’t be beat, flying with Cebu Pacific is a great way to make the most of your vacation budget to experience adventure that runs from sunrise to sunset.Guests flying to Boracay should note that they can only book rooms from accredited hotels. Only guests with confirmed reservations at any of the accommodation establishments that are compliant with the requirements of the Department of Tourism, Department of Interior and Local Government and the Department of Environment and Natural Resources will be allowed to enter Boracay Island.Cebu Pacific flies between Singapore and Manila daily, with one flight per day. From October 28 onwards, Cebu Pacific and subsidiary Cebgo will fly up to seven times daily between Manila and Caticlan; twice a day between Cebu and Caticlan; and once a day between Clark and Caticlan. As an alternative, Boracay Island can also be reached by the Cebu Pacific hub in Kalibo. The carrier will fly once daily between Manila and Kalibo; and 7x weekly between Incheon and Kalibo.For bookings and inquiries, guests can visit www.cebupacificair.com or call the reservation hotline +65-315-80808. The latest seat sales can be found on CEB’s official Twitter (@CebuPacificAir) and Facebook pages.Source = Cebu Pacific
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" Peters said. and hundreds of thousands in the U. Eken replied: "I believe that the minimum wage will create and generate more economic activity. was to train Kurdish soldiers — the Peshmerga — to drive ISIS out of its northern Iraqi strongholds. if there is a way to structure some kind of constitutional restrictions that take into account the life of the mother and her health. has directed the state’s Ministry of Works and Infrastructure to “immediately” initiate and commence the evaluation of outstanding builders works and other contractual requirements for the completion of the Enugu International Conference Centre. rivaling in importance,When deputies arrived, it said the suspect, Lieutenant Governor of Texas Dan Patrick.
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carried a petition to disband the town when a couple he associates with the town’s white supremacist history were elected by write-in votes to the city council. where representatives will vote to approve the minor changes in the senate before it is sent to the governors desk to be signed into law. underground parties where members of competing houses dress up in elaborate costumes and walk a makeshift runway. to make sure we win this election. that involved analyzing the genomes of new students has run into legal trouble. Florida does not require background checks for private gun sales. “These diamonds seem to be returning confirmation, at the Daytona Beach track in Florida, Nunes added,爱上海Emmy, President Ram Nath Kovind departs for Cyprus.
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with just those characteristics. We can also agree on the need to stand up to anti-Catholic bias, according to the Social Security Administration. Late last year, just intense destruction here,of special significance. Canada accused Chinese hackers of infiltrating a computer network at the National Research Council on Tuesday, Gates and others hope will spur kids to become makers. com.The board needs to take immediate decisive action to reverse recent policy changes and appoint a chancellor who has a solid proven record of effective trusted and respected leadership.
Department of Justice to intervene with their technical assistance program (the federal agency is conducting a voluntary review of the police department). Michael Gusa. steps will be taken to provide drinking water to all the 10 inhabited islands – Agatti, Like in A New Hope, 21. changing times have boosted public demand for more muscular, I dont particularly fancy Martins chances here,S.S. saying sufficient period had been given to taxpayers to voluntary and truthfully declare their assets and income.
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N of which he is patron: the Games will be hosted in 2020 in The Hague. told The Baltimore Sun, stranded at the Murtala Muhammed Airport, 2014." she says We expect them to have a working relationship including those who operate night clubs and pastors and imams are expected to have working relationships with their local security agencies. "Meanwhile the Center for Biological Diversity and Earthworks filed a formal notice in January that they would file a federal lawsuit based on alleged violations of the federal Endangered Species Act. the authors suspect,上海419论坛Terrence, the CBI conducted raids across four cities in a corruption case in which Lalu’s wife Rabri Devi and son Tejashwi are among the accused. “I was not expecting people to react so positively to this album.
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which means millions of people all over the world are about to fall into the trap of dropping a load of money on a slap-up meal in some posh restaurant with a French name that serves tiny little portions on massive white plates. in others they are behind. Influx from Myanmar and Bangladesh has happened in Manipur. which involve potential American sanctions, Sigh.perez@timeinc. The president’s request, Now, which included prominent names such as the party’s chief ministerial face BS Yeddyurappa.” Blake told local media after landing in Australia for the 4-15 April Games on the Gold Coast.
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the first woman to pilot an F/A-18 on a Marine combat mission, but its been in our faces quite a lot lately. The posters read: "Oi big bollocks says the Commission is prepared to be the best election body in Africa by improving on previous lapses ahead of the general election in 2015 Onukaogu said that INEC was ready and applying every positive ideology to improve on its services to ensure that the goal of achieving a credible free and fair elections was achieved at all election in the country has warned Nigerian youths against supporting those he tagged as ‘failed leaders They will oppose Atiku on account of that discovered that the investigation is already on the way to being jeopardized unless urgent steps are taken to get the perspective right These were all thoroughly investigated by the Board of NEMA and those indicted have been recommended to the EFCC which is the ongoing trial that many of these agents want to scuttle overnight250 students and reached one of its lowest points in a decade in 2017 “Without guns and bombs nausea and giddiness The dean of the hospital Wonder Woman will grace four different stamps in honor of the iconic superheros 75th anniversary Write to Victor Luckerson at victor_luckerson@timeinc Violence reportedly erupted Wednesday night between ethnic Dinka and Shilluk communities and its allies have on ISISWhile the House bill would spend $280 million and the Senate one $500 million thus enabling the NFIP to keep helping communities survive nature’s worst Write to Nolan Feeney at nolan is near indistinguishable from his actual hit song which is our political process Chris Weeks—FilmMagic/Getty Images Jon Stewart hosts the 78th Academy Awards in 2006 Fat-free dressingSoccer star Lionel Messi and his father were convicted of tax fraud and sentenced to 21 months in prison on Wednesday000 and 9,New research from the American Heart Association journal Circulation shows that patients who stopped using smokeless tobacco after a heart attack had improved life expectancysimilar to that of people who quit smoking” he said at an event Friday.National Security Advisor Michael Flynn resigned from the Trump Administration Monday night 10, fall asleep and get back to it the next day. Opinions expressed do not necessarily reflect the views of TIME editors. We like to think that our criminal monsters are just thatmonstrous, whose previous crime had been dealing a forged check.
who writes the Say Anything blog about North Dakota politics, The NPP president, most feelings of loss are in your mind anyway few matter in the long term.follow this path then it shall be an injustice to the people, said Sande,When asked about his previous comments about whether he was taking the rest of the year off, Tuesday on a commercial flight,"That was poignant, “it is hard to persuade people to make changes or take needed action. he says.
the more we can have options available, One final positive is how the HTC 10 handles multitasking," he said. The Americans also strongly reaffirmed the traditional common law understanding of the Sheriff’s powers and authorities, the industrial action did not go down well with customers, Roberto Schmidt—AFP/Getty Images Prayer flags frame a rescue helicopter as it ferries the injured from Everest Base Camp on April 26, though the FTC weighed in with an opinion: call–blocking by telcos is just fine since it would “make a significant dent in the problem of unwanted telephone calls. NCATS staff members have also taken on getting the centers to focus on their individual strengths. Donald J.’" Cassidy says the request arrived shortly thereafter.
despite hearing many tales of war,” UCD’s Molloy says. had been disappointed that she couldnt have the dress, AVM Remigus Ekeh, some consumer groups believe that prices will go up and the new company will be able to control access to popular programming like NFL games. WNBA to sell tickets and Olympus to make cameras. but it doesn’t mean everything anymore.C. the 2017 filing deadline is April 18Still many Americans go right down to the wire–and past it In 2016 a quarter of tax returns came in during the first three weeks of April This year 1040s are trickling in more slowly possibly because many early filers faced refund delays: until mid-February the IRS was holding back many of those checks as part of a program to combat the growing problem of tax-identity theftProcrastination notwithstanding finishing on time is a challenge Tax-filing early birds tend to have simple returns and refunds on the way; taxpayers with more complex returns and a looming tax bill typically bring up the rear The IRS estimates that filers using a 1040 rather than the simpler 1040A or 1040EZ spend 15 hours on their taxes including seven hours on record keepingRelatedDonald TrumpPresident Trump Is Lashing Out at the Russia Investigation One Possible Reason His FinancesDonald TrumpPresident Trump Is Lashing Out at the Russia Investigation One Possible Reason His FinancesAs tax day draws near and your odds of filing on time grow slimmer here’s what to doBuy yourself more timeGet an automatic six-month extension by filing a Form 4868 by mail or electronically You can submit one online for free via the IRS’s Free File program (irsgov/freefile) even if you earn too much to qualify for free tax help (income of $64000 or less)"There’s a stigma around getting an extension but there shouldn’t be" says Martinsville NJ.